Synthesis of Novel Piperidine Compounds as Anticholinesterase Agents
نویسندگان
چکیده
Donepezil is a piperidine based agent that is used for treatment of Alzheimer’s disases. This agent act as acetylcholine esterase inhibitor and therefore, synthesis of piperidine compounds to evaluate anticholinesterase activity is very popular field in medicinal chemistry [1]. Thus, in this study some novel piperidine derivatives were synthesized in order to observe their probable anticholinesterase effects. Structures of obtained compounds were confirmed by IR, 1 H-NMR 13 C-NMR and Mass spectroscopic methods. Anticholinesterase activity of the synthesized compounds were tested by using Ellman’s method [2]. Some of the compounds in the series indicated good enzyme inhibitory activity.
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